Cancer is a major health issue worldwide, and the global burden of cancer is expected to
increase in the coming years. Whereas the limited success with current therapies has driven …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

BACKGROUND: MicroRNAs (miRNAs) are small noncoding RNAs that regulate the
expression of approximately 60% of all human genes. They play important roles in …

The melanoma differentiation-associated gene-7 (mda-7; approved gene symbol IL24) is a
tumor suppressor gene whose expression induces selective apoptosis in tumor cells. To …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

IL-24 is a member of the IL-10 family of cytokines. In this study, we investigated IL-24
expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …

Abstract Interleukin (IL)-10 cytokine family members, including IL-10, IL-19, IL-20, IL-22, IL-
24, IL-26 and the distantly related IL-28A, IL-28B, and IL-29, play critical roles in the …

The family of IL‐10‐related cytokines includes several human members, IL‐19, IL‐20, IL‐22,
IL‐24 and IL‐26, and a series of herpesviral and poxviral paralogs. Some of these cytokines …

Interleukin 24 (IL-24) is an important pleiotropic immunoregulatory cytokine, whose gene is
located in human chromosome 1q32-33. IL-24's signaling pathways have diverse biological …