Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure of
autophagosomes. Cargo triggers the assembly of a web of cargo receptors and core …

An enigmatic step in de novo formation of the autophagosome membrane compartment is
the expansion of the precursor membrane phagophore, which requires the acquisition of …

The year of 2013 marked the 50th anniversary of C de Duve's coining of the term
“autophagy” for the degradation process of cytoplasmic constituents in the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …

Macroautophagy, hereafter autophagy, is a degradative process conserved among
eukaryotes, which is essential to maintain cellular homeostasis. Defects in autophagy lead …

Autophagy is a fundamental function of eukaryotic cells and is well conserved from yeast to
humans. The most remarkable feature of autophagy is the synthesis of double membrane …

Autophagy is a conserved process for the bulk degradation of cytoplasmic material.
Triggering of autophagy results in the formation of double membrane‐bound vesicles …

Autophagy is a bulk degradation system induced by cellular stresses such as nutrient
starvation. Its function relies on the formation of double-membrane vesicles called …