Highlights•Immune fitness in health and disease depends notably on the diversity of cellular
repertoires.•Single-cell sequencing is fostering the understanding of clonal diversity of T-cell …

Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …

Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …

The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …

Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical
element of successful vaccines and targeted immunotherapies. However, the underlying …

Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …

Tumor-associated peptide–human leukocyte antigen complexes (pHLAs) represent the
largest pool of cell surface–expressed cancer-specific epitopes, making them attractive …

The adaptive immune system uses two main types of antigen receptors: T-cell receptors
(TCRs) and antibodies. While both proteins share a globally similar β-sandwich architecture …

Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-
cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical …

Over the last half century, it has become well established that cancers can elicit a host
immune response that can target them with high specificity. Only within the last decade, with …