Precise regulation of mRNA translation is of fundamental importance for maintaining
homeostasis. Conversely, dysregulated general or transcript‐specific translation, as well as …

Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and
promotes host RNA decay. However, it is unclear how these two activities are connected …

Significance: Translation is an essential cellular process, and diverse signaling pathways
have evolved to deal with problems arising during translation. Erroneous stalls and …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing progressive
loss of motor neurons. Mutations in Fused in sarcoma (FUS) leading to its cytoplasmic …

ABSTRACT SARS-CoV-2, the causative agent of COVID-19, has been intensely studied in
search of effective antiviral treatments. The immunosuppressant cyclosporine A (CsA) has …

Ribosome-associated quality control (RQC), a ubiquitous process essential for maintaining
protein homeostasis in eukaryotes, acts as a critical surveillance system for protein …

Coronavirus disease 19 is caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) enveloped virus with a single-stranded positive-sense ribonucleic acid …

Myc is a major driver of tumor initiation, progression, and maintenance. Up-regulation of Myc
protein level rather than acquisition of neomorphic properties appears to underlie most Myc …

When host cells are infected with coronaviruses, the first viral protein produced is Nsp1. This
protein inhibits host protein synthesis and induces host mRNA degradation to enhance viral …

Caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), coronavirus
disease 2019 (COVID‐19) primarily manifests as respiratory dysfunction. However …