Impact of organophosphate pesticides exposure on human semen parameters and testosterone: a systematic review and meta-analysis

MA Hamed, TM Akhigbe, AE Adeogun… - Frontiers in …, 2023 - frontiersin.org
Background Organophosphate (OP) pesticides have been associated with a decline in
semen quality, although there are still considerable arguments about the magnitude of the …

Impact of hypoxia on male reproductive functions

PA Oyedokun, RE Akhigbe, LO Ajayi… - Molecular and Cellular …, 2023 - Springer
Male reproductive functions, which include testicular steroidogenesis, spermatogenesis, and
sexual/erectile functions are key in male fertility, but may be adversely altered by several …

[HTML][HTML] Glutamine prevents upregulation of NF-kB signaling and caspase 3 activation in ischaemia/reperfusion-induced testicular damage: An animal model

OA Afolabi, DC Anyogu, MA Hamed, AF Odetayo… - Biomedicine & …, 2022 - Elsevier
Aim Testicular ischaemia/reperfusion (I/R) injury is a major consequence of testicular torsion
with possible attendant risk of male infertility. Glutamine, on the other hand, is a known …

Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats

MA Hamed, RE Akhigbe, AO Aremu… - Chemico-Biological …, 2022 - Elsevier
Background Although highly active antiretroviral therapy (HAART) is effective in the
management of HIV, it has been reported to induce hepatic injury and non-alcoholic fatty …

Atorvastatin-mediated downregulation of VCAM-1 and XO/UA/caspase 3 signaling averts oxidative damage and apoptosis induced by ovarian ischaemia/reperfusion …

OA Afolabi, MA Hamed, DC Anyogu, DH Adeyemi… - Redox …, 2022 - Taylor & Francis
Background Oxidative damage is critical in the pathogenesis of ovarian
ischaemia/reperfusion (I/R) injury, and statins have been reported to exert antioxidant …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

Restoration of Hepatic and Intestinal Integrity by Phyllanthus amarus Is Dependent on Bax/Caspase 3 Modulation in Intestinal Ischemia-/Reperfusion-Induced Injury

AO Afolabi, TM Akhigbe, AF Odetayo, DC Anyogu… - Molecules, 2022 - mdpi.com
Ethnopharmacological relevance: Oxidative stress is a key player in intestinal
ischemia/reperfusion (I/R) injury (IIRI) with a tendency to trigger systemic inflammatory …

Orange peel extract and physical exercise synergistically ameliorate type 2 diabetes mellitus-induced dysmetabolism by upregulating GLUT4 concentration in male …

LA Olayaki, KB Okesina, JD Jesubowale… - Journal of Medicinal …, 2023 - liebertpub.com
Diabetes mellitus (DM) is a chronic disease and one of the oldest known disorders. It is
characterized by dysglycemia, dyslipidemia, insulin resistance (IR), and pancreatic cell …

In vivo exposure to bisphenol F induces oxidative testicular toxicity: role of Erβ and p53/Bcl-2 signaling pathway

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Reproductive …, 2023 - frontiersin.org
Introduction Bisphenol F (BPF), an alternative to bisphenol A has been implicated as a
gonadotoxic substance. BPF has been shown to induce hormonal imbalance and testicular …

Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3

OA Afolabi, TM Akhigbe, RE Akhigbe… - Frontiers in …, 2022 - frontiersin.org
Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in
various organs, but there is a paucity of data on its role in IIRI. Also, no reports were found …