Light in gold catalysis

S Witzel, ASK Hashmi, J Xie - Chemical Reviews, 2021 - ACS Publications
Within the wide family of gold-catalyzed reactions, gold photocatalysis intrinsically features
unique elementary steps. When gold catalysis meets photocatalysis, a valence change of …

Triptolide and its derivatives as cancer therapies

P Noel, DD Von Hoff, AK Saluja, M Velagapudi… - Trends in …, 2019 - cell.com
Triptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor,
immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor …

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics

Y Yang, J Kitagaki, RM Dai, YC Tsai, KL Lorick… - Cancer research, 2007 - AACR
The conjugation of proteins with ubiquitin plays numerous regulatory roles through both
proteasomal-dependent and nonproteasomal-dependent functions. Alterations in …

Natural products for the treatment of autoimmune arthritis: their mechanisms of action, targeted delivery, and interplay with the host microbiome

S Dudics, D Langan, RR Meka, SH Venkatesha… - International Journal of …, 2018 - mdpi.com
Rheumatoid arthritis (RA) is a chronic, debilitating illness characterized by painful swelling
of the joints, inflammation of the synovial lining of the joints, and damage to cartilage and …

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

AM Brinker, J Ma, PE Lipsky, I Raskin - Phytochemistry, 2007 - Elsevier
Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history
of use in traditional Chinese medicine. In recent years there has been considerable interest …

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

ZL Zhou, YX Yang, J Ding, YC Li, ZH Miao - Natural product reports, 2012 - pubs.rsc.org
Covering: 1972 to 2011 Triptolide, a principal bioactive ingredient of Tripterygium wilfordii
Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid …

Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

D Qiu, PN Kao - Drugs in R & D, 2003 - Springer
Extracts of Tripterygium wilfordii hook. f.(leigong teng, Thundergod vine) are effective in
traditional Chinese medicine for treatment of immune inflammatory diseases including …

Application and mechanisms of triptolide in the treatment of inflammatory diseases—a review

K Yuan, X Li, Q Lu, Q Zhu, H Jiang, T Wang… - Frontiers in …, 2019 - frontiersin.org
Bioactive compounds from medicinal plants with anti-inflammatory and immunosuppressive
effects have been emerging as important sources of drugs for the treatment of inflammatory …

Triptolide inhibits the growth and metastasis of solid tumors

S Yang, J Chen, Z Guo, XM Xu, L Wang, XF Pei… - Molecular cancer …, 2003 - AACR
Triptolide (TPL), a diterpenoid triepoxide purified from the Chinese herb Tripterygium
wilfordii Hook F, was tested for its antitumor properties in several model systems. In vitro …

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F

BJ Chen - Leukemia & lymphoma, 2001 - Taylor & Francis
Triptolide is a diterpenoid triepoxide purified from a Chines herb Tripterygium Wilfordii Hook
F (TWHF). TWHF has been used in traditional Chinese medicine for more than two thousand …