[HTML][HTML] Therapeutic innovations for geographic atrophy: A promising horizon

EC de Oliveira Figueiredo, C Bucolo… - Current Opinion in …, 2024 - Elsevier
This mini review spotlights the most promising treatments for geographic atrophy, the
advanced form of age-related macular degeneration, often resulting in severe and …

Cell death in AMD: The rationale for targeting Fas

DN Zacks, AJ Kocab, JJ Choi… - Journal of Clinical …, 2022 - mdpi.com
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
developed world. While great advances have been made in the treatment of the neovascular …

Clinical validation for automated geographic atrophy monitoring on OCT under complement inhibitory treatment

J Mai, D Lachinov, S Riedl, GS Reiter, WD Vogl… - Scientific Reports, 2023 - nature.com
Geographic atrophy (GA) represents a late stage of age-related macular degeneration,
which leads to irreversible vision loss. With the first successful therapeutic approach, namely …

Comparison of fundus autofluorescence versus optical coherence tomography–based evaluation of the therapeutic response to pegcetacoplan in geographic atrophy

J Mai, S Riedl, GS Reiter, D Lachinov, WD Vogl… - American Journal of …, 2022 - Elsevier
Purpose To perform an optical coherence tomography (OCT)-based analysis of geographic
atrophy (GA) progression in patients treated with pegcetacoplan. Design Post hoc analysis …

Resvega, a nutraceutical preparation, affects NFκB pathway and prolongs the anti-VEGF effect of bevacizumab in undifferentiated ARPE-19 retina cells

R Sghaier, M Perus, C Cornebise, F Courtaut… - International Journal of …, 2022 - mdpi.com
Age-related macular degeneration (AMD) is an irreversible chronic degenerative pathology
that affects the retina. Despite therapeutic advances thanks to the use of anti-vascular …

Sustained release of heme–albumin as a potential novel therapeutic approach for age-related macular degeneration

MM Allyn, MA Rincon-Benavides, HL Chandler… - Biomaterials …, 2022 - pubs.rsc.org
Globally, age-related macular degeneration (AMD) is the third most common visual
impairment. Most often attributed to cellular fatigue with aging, over expression of reactive …

[HTML][HTML] Progression dynamics of early versus later stage atrophic lesions in nonneovascular age-related macular degeneration using quantitative OCT biomarker …

LM Coulibaly, GS Reiter, P Fuchs, D Lachinov… - Ophthalmology …, 2023 - Elsevier
Purpose To investigate the progression of geographic atrophy secondary to nonneovascular
age-related macular degeneration in early and later stage lesions using artificial intelligence …

[HTML][HTML] METformin for the MINimization of Geographic Atrophy Progression (METforMIN): A Randomized Trial

LL Shen, JD Keenan, N Chahal, AT Taha… - Ophthalmology …, 2024 - Elsevier
Purpose Metformin use has been associated with a decreased risk of age-related macular
degeneration (AMD) progression in observational studies. We aimed to evaluate the efficacy …

[PDF][PDF] Comparison of FAF versus OCT-based evaluation of the therapeutic response to pegcetacoplan in geographic atrophy

J Mai, S Riedl, GS Reiter, D Lachinov… - Am J …, 2022 - optima.meduniwien.ac.at
Purpose: To perform an optical coherence tomography (OCT)-based analysis of atrophy
progression in patients treated wit Page 1 Abstract Purpose: To perform an optical coherence …

Intravitreal treatment for geographic atrophy: coming soon to a patient near you?

C Dinah, J Enoch, A Ghulakhszian, DJ Taylor… - Eye, 2022 - nature.com
Geographic atrophy (GA) is estimated to account for onequarter of legal blindness in the UK
[1], with an estimated prevalence of 276,000 cases in the UK in 2012 compared to 263,000 …