Rationale Cannabidiol (CBD) products lacking regulatory approval are being used to self-
treat a myriad of conditions and for their unsubstantiated health benefits. The scientific …

Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Cannabis (Cannabis sativa L.) plants from the family Cannabidaceae have been used since
ancient times, to produce fibers, oil, and for medicinal purposes. Psychoactive delta-9 …

Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Summary Δ 9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced
by the same Cannabis plant and have similar chemical structures but differ dramatically in …

Stress affects a constellation of physiological systems in the body and evokes a rapid shift in
many neurobehavioral processes. A growing body of work indicates that the …