Lyophilization and development of solid protein pharmaceuticals

W Wang - International journal of pharmaceutics, 2000 - Elsevier
Developing recombinant protein pharmaceuticals has proved to be very challenging
because of both the complexity of protein production and purification, and the limited …

Plant responses to drought, acclimation, and stress tolerance

I Yordanov, V Velikova, T Tsonev - Photosynthetica, 2000 - Springer
At the whole plant level, the effect of stress is usually perceived as a decrease in
photosynthesis and growth. That is why this review is focused mainly on the effect of drought …

Interactions of formulation excipients with proteins in solution and in the dried state

S Ohtake, Y Kita, T Arakawa - Advanced drug delivery reviews, 2011 - Elsevier
A variety of excipients are used to stabilize proteins, suppress protein aggregation, reduce
surface adsorption, or to simply provide physiological osmolality. The stabilizers encompass …

The continuing conundrum of the LEA proteins

A Tunnacliffe, MJ Wise - Naturwissenschaften, 2007 - Springer
Research into late embryogenesis abundant (LEA) proteins has been ongoing for more than
20 years but, although there is a strong association of LEA proteins with abiotic stress …

LEA proteins during water stress: not just for plants anymore

SC Hand, MA Menze, M Toner… - Annual review of …, 2011 - annualreviews.org
Late embryogenesis abundant (LEA) proteins are extremely hydrophilic proteins that were
first identified in land plants. Intracellular accumulation is tightly correlated with acquisition of …

[图书][B] Rational design of stable lyophilized protein formulations: theory and practice

JF Carpenter, BS Chang, W Garzon-Rodriguez… - 2002 - Springer
For ease of preparation and cost containment by the manufacturer, and ease of handling by
the end user, an aqueous therapeutic protein formulation usually is preferred. However, with …

Glass transition and food technology: A critical appraisal

ML Meste, D Champion, G Roudaut… - Journal of Food …, 2002 - Wiley Online Library
Most low water content or frozen food products are partly or fully amorphous. This review will
discuss the extent to which it is possible to understand and predict their behavior during …

Glass formation in plant anhydrobiotes: survival in the dry state

J Buitink, O Leprince - Cryobiology, 2004 - Elsevier
Anhydrobiotes can resist complete dehydration and survive the dry state for extended
periods of time. During drying, cytoplasmic viscosity increases dramatically and in the dry …

Lessons from nature: the role of sugars in anhydrobiosis

LM Crowe - Comparative Biochemistry and Physiology Part A …, 2002 - Elsevier
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A Fourier-transform infrared spectroscopy study of sugar glasses

WF Wolkers, AE Oliver, F Tablin, JH Crowe - Carbohydrate research, 2004 - Elsevier
Fourier-transform infrared spectroscopy (FTIR) was used to study the hydrogen-bonding
interactions that take place in vitrified carbohydrates of different chain lengths. The band …