Uncovering the genetic and evolutionary basis of local adaptation is a major focus of
evolutionary biology. The recent development of cost-effective methods for obtaining high …

The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Despite great progress in identifying genetic variants that influence human disease, most
inherited risk remains unexplained. A more complete understanding requires genome-wide …

The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan …

Previous genome-wide scans of positive natural selection in humans have identified a
number of non-neutrally evolving genes that play important roles in skin pigmentation …

Selective sweeps can increase genetic differentiation among populations and cause allele
frequency spectra to depart from the expectation under neutrality. We present a likelihood …

We present a new haplotype-based statistic (nS L) for detecting both soft and hard sweeps
in population genomic data from a single population. We compare our new method with …

Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …

Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …