Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …

The coronaviral spike is the dominant viral antigen and the target of neutralizing antibodies.
We show that SARS-CoV-2 spike binds biliverdin and bilirubin, the tetrapyrrole products of …

Most cells store metabolic energy in lipid droplets (LDs). LDs are composed of a
hydrophobic core, covered by a phospholipid monolayer, and functionalized by a specific …

Abstract Serine Incorporator 5 (SERINC5), a cellular multipass transmembrane protein that
is involved in sphingolipid and phosphatydilserine biogenesis, potently restricts a number of …

The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …

Serine incorporator (SERINC) proteins 1–5 (SERINC1-5) are involved in the progression of
several diseases. SERINC2-4 are carrier proteins that incorporate the polar amino acid …

To enter a cell and establish infection, HIV must first fuse its lipid envelope with the host cell
plasma membrane. Whereas the process of HIV membrane fusion can be tracked by …

Serine incorporator protein 5 (SERINC5) is the host antiretroviral factor that reduces HIV-1
infectivity by incorporating into virions and inhibiting the envelope glycoprotein (Env) …

Although it has long been proposed that membrane proteins may contain tightly bound
lipids, their identity, the structure of their binding sites, and their functional and structural …

The host restriction factor, Serinc5, incorporates into budding HIV particles and inhibits their
infection by an incompletely understood mechanism. We have previously reported that …