Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer
susceptibility; its protein structure and acetylation capacity results from the polymorphism's …

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Arylamine N-acetyltransferase 2 (NAT2) is involved in human physiological responses to a
variety of xenobiotic compounds, including common therapeutic drugs and exogenous …

Abstract Background The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the
metabolism of many drugs and xenobiotics. As it represents a likely target of population …

Objectives To describe the population pharmacokinetics of rifampicin, pyrazinamide and
isoniazid in children and evaluate the adequacy of steady-state exposures. Patients and …

SETTING: Isoniazid (INH) is related to the development of hepatotoxicity in some patients.
OBJECTIVE: To investigate the role of N-acetyl transferase 2 (NAT2) and cytochrome P450 …

Aims: TB is a serious global public health problem. Isoniazid, a key drug used to treat latent
TB, can cause hepatotoxicity in some patients. This pilot study investigated the effects of …

Background Dietary changes associated to shifts in subsistence strategies during human
evolution may have induced new selective pressures on phenotypes, as currently held for …

Background Genetic variation at NAT2 has been long recognized as the cause of differential
ability to metabolize a wide variety of drugs of therapeutic use. Here, we explore the pattern …

Functional variability at the arylamine N-acetyltransferase genes is associated with drug
response in humans and may have been adaptive in the past owing to selection pressure …