Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi… - Journal of hematology & …, 2022 - Springer
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

An ER‐targeting iridium (III) complex that induces immunogenic cell death in non‐small‐cell lung cancer

L Wang, R Guan, L Xie, X Liao, K Xiong… - Angewandte …, 2021 - Wiley Online Library
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti‐tumor
immunity. An iridium (III) complex (Ir1), containing an N, N‐bis (2‐chloroethyl)‐azane …

A highly potent ruthenium (II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

C Liang, J Xie, S Luo, C Huang, Q Zhang… - Nature …, 2021 - nature.com
As a basic structure of most polypyridinal metal complexes,[Ru (bpy) 3] 2+, has the
advantages of simple structure, facile synthesis and high yield, which has great potential for …

Metal drugs and the anticancer immune response

B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

Smart nanovesicle-mediated immunogenic cell death through tumor microenvironment modulation for effective photodynamic immunotherapy

W Yang, F Zhang, H Deng, L Lin, S Wang, F Kang… - ACS …, 2019 - ACS Publications
Combination therapy that could better balance immune activation and suppressive signals
holds great potential in cancer immunotherapy. Herein, we serendipitously found that the pH …

Rational design of a minimalist nanoplatform to maximize immunotherapeutic efficacy: Four birds with one stone

S Zhou, Q Shang, N Wang, Q Li, A Song… - Journal of Controlled …, 2020 - Elsevier
Chemotherapy sometimes can cause potential tumor-specific T-cell-mediated immune
response via stimulating immunogenic cell death (ICD). However, such immune response is …

Advancement of cancer immunotherapy using nanoparticles-based nanomedicine

V Gowd, A Ahmad, M Tarique, M Suhail… - Seminars in cancer …, 2022 - Elsevier
Cancer has complex pathophysiology and is one of the primary causes of death and
morbidity across the world. Chemotherapy, targeted therapy, radiation therapy, and …

Recent advances of redox-responsive nanoplatforms for tumor theranostics

M Chen, D Liu, F Liu, Y Wu, X Peng, F Song - Journal of Controlled …, 2021 - Elsevier
Nano-biotechnologies which combine diagnosis with therapy in an integrated nanoplatform
provide a promising prospect for cancer theranostics. Currently, the development of …

Nanovaccines with cell-derived components for cancer immunotherapy

Z Meng, Y Zhang, X Zhou, J Ji, Z Liu - Advanced drug delivery reviews, 2022 - Elsevier
Cancer nanovaccines as one of immunotherapeutic approaches are able to attack tumors by
stimulating tumor-specific immunological responses. However, there still exist multiple …