Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis
Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are
increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a …
increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a …
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
Vitamin D combined with pioglitazone mitigates type-2 diabetes-induced hepatic injury through targeting inflammation, apoptosis, and oxidative stress
HA Hamouda, SM Mansour, MF Elyamany - Inflammation, 2022 - Springer
Inflammation is a major pathophysiological factor in development of type-2 diabetes mellitus
(T2DM). Vitamin D (VITD) plays an imperative role in modulation of several inflammatory …
(T2DM). Vitamin D (VITD) plays an imperative role in modulation of several inflammatory …
Crosstalk between Aldosterone and Glycation through Rac-1 Induces Diabetic Nephropathy
Background: Advanced glycation end products (AGEs) interaction with its receptor (RAGE)
and aldosterone (Aldo) through the mineralocorticoid receptor (MR) activates Rac-1 and NF …
and aldosterone (Aldo) through the mineralocorticoid receptor (MR) activates Rac-1 and NF …
Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies
I Berdowska, M Matusiewicz, I Fecka - Molecules, 2023 - mdpi.com
Methylglyoxal (MGO) is the major compound belonging to reactive carbonyl species (RCS)
responsible for the generation of advanced glycation end products (AGEs). Its upregulation …
responsible for the generation of advanced glycation end products (AGEs). Its upregulation …
Pioglitazone attenuates advanced glycation end products‐induced apoptosis and calcification by modulating autophagy in tendon‐derived stem cells
L Xu, K Xu, Z Wu, Z Chen, Y He, C Ma… - Journal of Cellular …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is one of the prominent risk factors for pathological development and
progression of tendinopathy. One feature of DM‐related changes in tendinopathy is …
progression of tendinopathy. One feature of DM‐related changes in tendinopathy is …
Syzygium cumini (L.) skeels mitigate diabetic nephropathy by regulating Nrf2 pathway and mitocyhondrial dysfunction: In vitro and in vivo studies
Ethnopharmacological prevalence Hyperglycemia in diabetes increases the generation of
advanced glycation end products (AGEs) through non-enzymatic reactions. The interaction …
advanced glycation end products (AGEs) through non-enzymatic reactions. The interaction …
Mechanistic role of Syzygium cumini (L.) Skeels in glycation induced diabetic nephropathy via RAGE–NF–κB pathway and extracellular proteins modifications: A …
Ethnopharmacology relevance Syzygium cumini (L.) Skeels (SC), an ancient medicinal
plant, is used as a complementary and alternative medicine for treating diabetes mellitus …
plant, is used as a complementary and alternative medicine for treating diabetes mellitus …
[HTML][HTML] Evaluation of Potential Furin Protease Inhibitory Properties of Pioglitazone, Rosiglitazone, and Pirfenidone: An In Silico Docking and Molecular Dynamics …
AS Carranza-Aranda, CD Diaz-Palomera… - Current Issues in …, 2024 - mdpi.com
Furin (Fur) is a member of the protease convertase family; its expression is crucial for
cleaving and maturing many proteins. Fur also represents a therapeutic target in cancer …
cleaving and maturing many proteins. Fur also represents a therapeutic target in cancer …
[HTML][HTML] Pioglitazone in diabetic kidney disease: forgotten but not gone
GS Papaetis - Archives of Medical sciences. Atherosclerotic …, 2022 - ncbi.nlm.nih.gov
Diabetic kidney disease (DKD) is described in approximately 20–40% of all diabetic patients
and is associated with significant cardiovascular and all-cause mortality. The involvement of …
and is associated with significant cardiovascular and all-cause mortality. The involvement of …