One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …

Long non-coding RNAs (lncRNAs), which represent a new frontier in molecular biology, play
important roles in regulating gene expression at epigenetic, transcriptional and post …

Maternally expressed gene 3 (MEG3) is an imprinted gene highly expressed in the human
pituitary. However, MEG3 expression is lost in human gonadotroph-derived pituitary …

The ability of double-stranded DNA to form a triple-helical structure by hydrogen bonding
with a third strand is well established, but the biological functions of these structures remain …

Novel, profound and unexpected roles of long non-coding RNAs (lncRNAs) are emerging in
critical aspects of gene regulation. Thousands of lncRNAs have been recently discovered in …

Group II introns are self-splicing, mobile genetic elements that have fundamentally
influenced the organization of terrestrial genomes. These large ribozymes remain important …

Group II introns are some of the largest ribozymes in nature, and they are a major source of
information about RNA assembly and tertiary structural organization. These introns are of …

Estimates of the total number of bacterial species,, indicate that existing DNA sequence
databases carry only a tiny fraction of the total amount of DNA sequence space represented …

Prp8 is the largest and most highly conserved protein of the spliceosome, encoded by all
sequenced eukaryotic genomes but missing from prokaryotes and viruses. Despite all …