Therapeutic Target Identification and Inhibitor Screening against Riboflavin Synthase of Colorectal Cancer Associated Fusobacterium nucleatum
NA Alturki, MM Mashraqi, K Jalal, K Khan, Z Basharat… - Cancers, 2022 - mdpi.com
Simple Summary More and more studies are suggesting the role of microbes in several
diseases in addition to the germline and environmental factors. F. nucleatum is recently …
diseases in addition to the germline and environmental factors. F. nucleatum is recently …
Pan-genome mediated therapeutic target mining in Kingella kingae and inhibition assessment using traditional Chinese medicinal compounds: an informatics …
Z Basharat, A Meshal - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Kingella kingae causes bacteremia, endocarditis, osteomyelitis, septic arthritis, meningitis,
spondylodiscitis, and lower respiratory tract infections in pediatric patients. Usually it …
spondylodiscitis, and lower respiratory tract infections in pediatric patients. Usually it …
Pan-Genomics of Escherichia albertii for Antibiotic Resistance Profiling in Different Genome Fractions and Natural Product Mediated Intervention: In Silico Approach
K Jalal, K Khan, A Hayat, SM Alnasser, A Meshal… - Life, 2023 - mdpi.com
Escherichia albertii is an emerging, enteric pathogen of significance. It was first isolated in
2003 from a pediatric diarrheal sample from Bangladesh. In this study, a comprehensive in …
2003 from a pediatric diarrheal sample from Bangladesh. In this study, a comprehensive in …
Therapeutic target mapping from the genome of Kingella negevensis and biophysical inhibition assessment through PNP synthase binding with traditional medicinal …
Z Basharat, Z Murtaza, A Siddiqa, SM Alnasser… - Molecular Diversity, 2024 - Springer
Kingella negevensis belongs to the Neisseriaceae family. It is implied that it has significant
virulence potential due to RTX toxin production, which can cause hemolysis. It usually …
virulence potential due to RTX toxin production, which can cause hemolysis. It usually …
Exploring Lead‐Like Molecules of Traditional Chinese Medicine for Treatment Quest against Aliarcobacter butzleri: In Silico Toxicity Assessment, Dynamics …
Background. Aliarcobacter butzleri is a Gram‐negative, curved or spiral‐shaped,
microaerophilic bacterium and causes human infections, specifically diarrhea, fever, and …
microaerophilic bacterium and causes human infections, specifically diarrhea, fever, and …
[HTML][HTML] Identification of therapeutic drug target of Shigella Flexneri serotype X through subtractive genomic approach and in-silico screening based on drug …
MH Ahmed, K Khan, S Tauseef, K Jalal… - Infection, Genetics and …, 2024 - Elsevier
Shigellosis, induced by Shigella flexneri, constitutes a significant health burden in
developing nations, particularly impacting socioeconomically disadvantaged communities …
developing nations, particularly impacting socioeconomically disadvantaged communities …
Pangenome diversification and resistance gene characterization in Salmonella Typhi prioritized RfaJ as a significant therapeutic marker
K Khan, K Jalal, R Uddin - Journal of Genetic Engineering and …, 2023 - Springer
Abstract Background Salmonella Typhi stands as the etiological agent responsible for the
onset of human typhoid fever. The pressing demand for innovative therapeutic targets …
onset of human typhoid fever. The pressing demand for innovative therapeutic targets …
Breaking resistance: in silico subtractive and comparative genomics approaches for drug targeting in Bacteroides fragilis
T Zia, K Khan, S Aghayeva, R Uddin - Biotechnology Letters, 2024 - Springer
The purpose of this study was to identify potential novel drug targets for Bacteroides fragilis
infections using bioinformatics techniques, such as subtractive and comparative genomics …
infections using bioinformatics techniques, such as subtractive and comparative genomics …
Subtractive sequence-mediated therapeutic targets from the conserved gene clusters of Campylobacter hyointestinalis and computational inhibition assessment
Campylobacter hyointestinalis is a causative agent of enteritis, proctitis, human
gastroenteritis, and diarrhea. Reported transmission is from pigs to humans. Link with …
gastroenteritis, and diarrhea. Reported transmission is from pigs to humans. Link with …
Two New Anti-SARS-CoV-2 Naphthoquinones from Cigar-Tobacco-Derived Endophytic Fusarium oxysporum
P Zhang, WY Liu, HY Liu, YP Wu, YK Li… - Chemistry of Natural …, 2024 - Springer
In this study, two new naphthoquinones, 6-isopropyl-7-methoxy-2-(2-oxopropyl)
naphthalene-1, 4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl) naphthalene-1, 4 …
naphthalene-1, 4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl) naphthalene-1, 4 …