Left ventricular assist-device (LVAD) implantation is a life-saving therapy for patients with
advanced heart failure (HF). With chronic unloading and circulatory support, LVAD …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Aims The ageing heart naturally incurs a progressive decline in function and perfusion that
available treatments cannot halt. However, some exceptional individuals maintain good …

Pathologies of the vasculature including the microvasculature are often complex in nature,
leading to loss of physiological homeostatic regulation of patency and adequate perfusion to …

Cardiovascular disease (CVD) is the leading cause of death worldwide. Current data
suggest that patients with cardiovascular diseases experience more serious complications …

Objective Cardiomyocyte senescence is an important contributor to cardiovascular diseases
and can be induced by stressors including DNA damage, oxidative stress, mitochondrial …

Although major pathogenesis mechanisms of heart failure (HF) are well established, the
significance of early (mal) adaptive structural changes of cardiomyocytes preceding …

Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent
among the elderly population. Urgent attention is required to prioritize preventive and …

In contrast to neonates and lower organisms, the adult mammalian heart lacks any capacity
to regenerate following injury. The vast majority of our understanding of cardiac …

The risk of developing chronic illnesses and disabilities is increasing with age. To predict
and prevent aging, biomarkers relevant to the aging process must be identified. This paper …