Therapeutic targeting of TGF‐β in lung cancer

S Aftabi, A Barzegar Behrooz, M Cordani… - The FEBS …, 2024 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology,
initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its …

Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?

A Mottais, L Riberi, A Falco, S Soccal, S Gohy… - International journal of …, 2023 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update

X Su, W Wu, Z Zhu, X Lin, Y Zeng - Respiratory research, 2022 - Springer
Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Pleiotropic effects of DCLK1 in cancer and cancer stem cells

D Chhetri, S Vengadassalapathy… - Frontiers in Molecular …, 2022 - frontiersin.org
Doublecortin-like kinase 1 (DCLK1), a protein molecule, has been identified as a tumor stem
cell marker in the cancer cells of gastrointestinal, pancreas, and human colon. DCLK1 …

Simultaneous solubilization and extended release of insoluble drug as payload in highly soluble particles of γ-cyclodextrin metal-organic frameworks

Y Liu, P Zhou, Z Cao, W Liang, J Yan, H Xu… - International Journal of …, 2022 - Elsevier
The inclusion and nanocluster formed in cyclodextrin-metal organic framework (CD-MOF)
make it a remarkable vehicle in improving the solubility and bioavailability of insoluble …

Nintedanib inhibits endothelial mesenchymal transition in bleomycin-induced pulmonary fibrosis via focal adhesion kinase activity reduction

WK Yu, WC Chen, VYF Su, HC Shen, HH Wu… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD). Pulmonary
fibroblasts play an important role in the development of IPF. Emerging evidence indicates …

Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy

Y Xu, Y Liu, Q Liu, S Lu, X Chen, W Xu, F Shi - Journal of Controlled …, 2021 - Elsevier
Albumin nanoparticles represent an approved anti-tumor drug delivery system. However,
there is only one albumin nanoparticle product (paclitaxel-albumin nanoparticle) on the …

Addition of polyphenols to drugs: the potential of controlling “inflammaging” and fibrosis in human senescent lung fibroblasts in vitro

MCX Godoy, GA Monteiro, BH Moraes… - International Journal of …, 2024 - mdpi.com
The combination of a polyphenol, quercetin, with dasatinib initiated clinical trials to evaluate
the safety and efficacy of senolytics in idiopathic pulmonary fibrosis, a lung disease …

Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as …

Z Wu, M Jia, W Zhao, X Huang, X Yang, D Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Schisandra chinensis decoction derived from the book of
Waitai Miyao (Tao Wang, Tang dynasty) is often used in the treatment of idiopathic …

Shifting paradigms for suppressing fibrosis in kidney transplants: supplementing perfusion solutions with anti-fibrotic drugs

LL van Leeuwen, HGD Leuvenink, P Olinga… - Frontiers in …, 2022 - frontiersin.org
Great efforts have been made toward addressing the demand for donor kidneys. One of the
most promising approaches is to use kidneys from donation after circulatory death donors …