In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Until today the role of oxygen in the development of the fetus remains controversially
discussed. It is still believed that lack of oxygen in utero might be responsible for some of the …

Lysosomes, with their arsenal of degradative enzymes are increasingly becoming an area of
interest in the field of oncology. The changes induced in this compartment upon …

Stem cell transplantation may repair the injured heart, but tissue regeneration is limited by
death of transplanted cells. Most cell death occurs in the first few days post-transplantation …

Human embryonic stem cells (hESCs) offer the opportunity to replenish cells lost in the
postinfarct heart. We explored whether human myocardium could be generated in rat hearts …

Chaperones (stress proteins) are essential proteins to help the formation and maintenance
of the proper conformation of other proteins and to promote cell survival after a large variety …

Myocardial ischemia-reperfusion (IR) injury can cause ventricular cell death and is a major
pathological event leading to morbidity and mortality in those with coronary artery disease …

Myocardial ischemia–reperfusion (IR) injury is a major contributor to the morbidity and
mortality associated with coronary artery disease. Muscular exercise is a countermeasure to …

Toll-like receptors (TLRs) represent the first line of host defense against microbial infection
and play a pivotal role in both innate and adaptive immunity. TLRs recognize invading …

Although heat-shock preconditioning has been shown to promote cell survival under
oxidative stress, the nature of heat-shock response from different cells is variable and …