Objective Chronic rhinosinusitis (CRS) is a heterogeneous disorder with distinct
pathophysiologic mechanisms. Based on transcription factor expression and cytokine …

Taste receptors, first identified on the tongue, are best known for their role in guiding our
dietary preferences. The expression of taste receptors for umami, sweet, and bitter have …

It is increasingly recognized that chronic rhinosinusitis (CRS) comprises a spectrum of
different diseases with distinct clinical presentations and pathogenic mechanisms. Defining …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

Chronic rhinosinusitis has a significant impact on patient quality of life, creates billions of
dollars of annual healthcare costs, and accounts for∼ 20% of adult antibiotic prescriptions in …

Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2
taste cells of the tongue, but are also expressed in other tissues throughout the body …

Bitter and sweet taste G protein-coupled receptors (known as T2Rs and T1Rs, respectively)
were originally identified in type II taste cells on the tongue, where they signal perception of …

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Bitter (T2R) and sweet (T1R) taste receptors have been implicated in sinonasal innate
immunity and in the pathophysiology of chronic rhinosinusitis (CRS). Taste receptors are …