[HTML][HTML] My battle with cancer. Part 1

MV Blagosklonny - Oncoscience, 2024 - ncbi.nlm.nih.gov
In January 2023, diagnosed with numerous metastases of lung cancer in my brain, I felt that I
must accomplish a mission. If everything happens for a reason, my cancer, in particular, I …

Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review

P Pospisil, L Hynkova, L Hnidakova… - Frontiers in …, 2024 - frontiersin.org
Background The landscape of brain metastases radiotherapy is evolving, with a shift away
from whole-brain radiotherapy (WBRT) toward targeted stereotactic approaches aimed at …

[HTML][HTML] Efficacy, safety, and health-related quality of life with camrelizumab plus pemetrexed and carboplatin as first-line treatment for advanced nonsquamous …

X Hou, C Zhou, G Wu, W Lin, Z Xie, H Zhang… - Journal of Thoracic …, 2023 - Elsevier
Introduction Systemic treatment options for NSCLC with brain metastases (BMs) are scarce.
We evaluated the activity and safety of camrelizumab plus chemotherapy as first-line therapy …

Cognitive flexibility is selectively impaired by radiation and is associated with differential recruitment of adult-born neurons

EM Amelchenko, DV Bezriadnov… - Journal of …, 2023 - Soc Neuroscience
Exposure to elevated doses of ionizing radiation, such as those in therapeutic procedures,
catastrophic accidents, or space exploration, increases the risk of cognitive dysfunction. The …

Cognitive Symptoms Across Diverse Cancers

SJ Mayo, K Edelstein, EG Atenafu, R Ajaj… - JAMA Network …, 2024 - jamanetwork.com
Importance Psychosocial health services for adults with cancer should include support for
cognitive symptoms and symptom clusters. Objective To characterize the frequency and …

AOP report: Development of an adverse outcome pathway for deposition of energy leading to learning and memory impairment

A Sleiman, KB Miller, D Flores, J Kuan… - Environmental and …, 2024 - Wiley Online Library
Understanding radiation‐induced non‐cancer effects on the central nervous system (CNS)
is essential for the risk assessment of medical (eg, radiotherapy) and occupational (eg …

Evaluation of alterations in interstitial fluid dynamics in cases of whole‐brain radiation using the diffusion‐weighted image analysis along the perivascular space …

T Taoka, R Ito, R Nakamichi, T Nakane… - NMR in …, 2024 - Wiley Online Library
In the current study, we assessed changes in interstitial fluid dynamics resulting after whole‐
brain radiotherapy using the diffusion‐weighted image analysis along the perivascular …

Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation

GA Zisiadis, A Alevyzaki, E Nicola… - Frontiers in …, 2023 - frontiersin.org
Introduction Cranial irradiation (IR) negatively regulates hippocampal neurogenesis and
causes cognitive dysfunctions in cancer survivors, especially in pediatric patients. IR …

[HTML][HTML] Multidisciplinary management of HER2-positive breast cancer with brain metastases: an evidence-based pragmatic approach moving from pathophysiology to …

G Giordano, G Griguolo, M Landriscina… - Critical Reviews in …, 2023 - Elsevier
Abstract INTRODUCTION About 30-50% of stage IV HER2+ breast cancers (BC) will present
brain metastases (BMs). Their management is based on both local treatment and systemic …

[HTML][HTML] Nivolumab plus ipilimumab with chemotherapy for non–small cell lung cancer with untreated brain metastases: A multicenter single-arm phase 2 trial (NIke …

Y Tsuchiya-Kawano, Y Shiraishi, K Tanaka… - European Journal of …, 2024 - Elsevier
Background The effect of dual immunotherapy combined with platinum-based
chemotherapy on untreated brain metastases derived from non–small cell lung cancer …