Diabetes is associated with excess morbidity and mortality due to both micro-and
macrovascular complications, as well as a range of non-classical comorbidities. Diabetes …

Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging
them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains …

Genetic studies have identified numerous loci associated with type 2 diabetes (T2D), but the
functional roles of many loci remain unexplored. Here, we engineered isogenic knockout …

White adipocytes function as major energy reservoirs in humans by storing substantial
amounts of triglycerides, and their dysfunction is associated with metabolic disorders; …

Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by
modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was …

Objective Human functional genomics has proven powerful in discovering drug targets for
common metabolic disorders. Through this approach, we investigated the involvement of the …

The aging process is a complex and multifaceted phenomenon affecting all living
organisms. It involves a gradual deterioration of tissue and cellular function, leading to a …

Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a
regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide …

Annotating genetic variants to their target genes is of great importance in unraveling the
causal variants and genetic mechanisms that underlie complex diseases. However, disease …

Objective Heterozygous pathogenic or likely pathogenic (P/LP) PDX1 variants cause
monogenic diabetes. We comprehensively examined the phenotypes of carriers of P/LP …