Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
mRNA vaccines for infectious diseases—advances, challenges and opportunities
The concept of mRNA-based vaccines emerged more than three decades ago.
Groundbreaking discoveries and technological advancements over the past 20 years have …
Groundbreaking discoveries and technological advancements over the past 20 years have …
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
To elicit optimal immune responses, messenger RNA vaccines require intracellular delivery
of the mRNA and the careful use of adjuvants. Here we report a multiply adjuvanted mRNA …
of the mRNA and the careful use of adjuvants. Here we report a multiply adjuvanted mRNA …
Recent advances in nanoparticulate RNA delivery systems
Nanoparticle-based RNA delivery has shown great progress in recent years with the
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
approval of two mRNA vaccines for Severe Acute Respiratory Syndrome Coronavirus 2 …
Mechanical release of homogenous proteins from supramolecular gels
A long-standing challenge is how to formulate proteins and vaccines to retain function
during storage and transport and to remove the burdens of cold-chain management. Any …
during storage and transport and to remove the burdens of cold-chain management. Any …
Advances in the design and delivery of RNA vaccines for infectious diseases
RNA medicines represent a paradigm shift in treatment and prevention of critical diseases of
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
global significance, eg, infectious diseases. The highly successful messenger RNA (mRNA) …
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
Ionizable lipids are a key component of lipid nanoparticles, the leading nonviral messenger
RNA delivery technology. Here, to advance the identification of ionizable lipids beyond …
RNA delivery technology. Here, to advance the identification of ionizable lipids beyond …
Recent advances in micro-and nano-scale carrier systems for controlled delivery of vaccines
Vaccines provide substantial safety against infectious diseases, saving millions of lives each
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …
year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing …
Rapid induction of long-lasting systemic and mucosal immunity via Thermostable Microneedle-Mediated Chitosan Oligosaccharide-Encapsulated DNA Nanoparticles
M Li, L Yang, C Wang, M Cui, Z Wen, Z Liao, Z Han… - Acs Nano, 2023 - ACS Publications
Most existing vaccines, delivered by intramuscular injection (IM), are typically associated
with stringent storage requirements under cold-chain distribution and professional …
with stringent storage requirements under cold-chain distribution and professional …
Advanced technologies for the development of infectious disease vaccines
Vaccines play a critical role in the prevention of life-threatening infectious disease. However,
the development of effective vaccines against many immune-evading pathogens such as …
the development of effective vaccines against many immune-evading pathogens such as …