The phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a carbohydrate
transport and phosphorylation system present in bacteria of all different phyla and in …

Streptococcus pneumoniae, a Gram-positive bacterium, can cause a broad range of severe
diseases including pneumonia, septicemia and meningitis. The pneumococcal …

Streptococcus pneumoniae is a strictly fermentative human pathogen that relies on
carbohydrate metabolism to generate energy for growth. The nasopharynx colonized by the …

Streptococcus pneumoniae can regulate virulence gene expression by sensing
environmental changes, which is key to its pathogenicity. The global transcription regulator …

Streptococcus pneumoniae two-component regulatory systems (TCSs) are important
systems that perceive and respond to various host environmental stimuli. In this study, we …

Streptococcus pneumoniae persist in the human nasopharynx within organized biofilms.
However, expansion to other tissues may cause severe infections such as pneumonia, otitis …

Streptococcus pneumoniae (the pneumococcus) is a formidable human pathogen that is
capable of asymptomatically colonizing the nasopharynx. Progression from colonization to …

NAD (Nicotinamide Adenine Dinucleotide) biosynthesis is vital for bacterial physiology and
plays an important role in cellular metabolism. A naturally occurring vitamin B complex …

Background The polysaccharide capsule of Streptococcus pneumoniae plays a major role in
virulence, adherence to epithelial cells, and overall survival of the bacterium in the human …

In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39
to sialic acid (N-acetylneuraminic acid [Neu5Ac]). Transcriptome comparison of wild-type …