Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

E3 ligases carry out the final step in the ubiquitination cascade, catalyzing transfer of
ubiquitin from an E2 enzyme to form a covalent bond with a substrate lysine. Three distinct …

Proteins are dynamic entities that undergo a plethora of conformational changes that may
take place on a wide range of time scales. These changes can be as small as the rotation of …

The post-translational modification of proteins regulates many biological processes. Their
dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications …

The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …

Protein aggregation is a continuous process in our cells. Some proteins aggregate in a
regulated manner required for different vital functional processes in the cells whereas other …

The ubiquitin–proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation
pathways are integral to cellular protein homeostasis. The growing recognition of the …

Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of
the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant …

In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3
(NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in …