The production of monoclonal antibody (mAb) therapeutics, a rapidly growing multi-billion-
dollar enterprise in the biopharmaceutical industry, faces major challenges in achieving …

Highlights•Temporal evolution of N-glycosylation is of rising interest.•Rapid detection with
predictive modeling could enable dynamic control of N-glycosylation.•Combinations of …

Freeze drying is an essential unit operation for the storage of biopharmaceuticals, with its
main weakness being the very long primary drying times required to sublimate all of the ice …

Modulation of glycosylation in therapeutic proteins is a critical aspect to their development
and production. The levels of various glycan moieties greatly impact the therapeutic protein's …

Chinese hamster ovary (CHO) cell culture systems are the most widely used platform for the
industrial production of monoclonal antibodies (mAbs). The optimisation of manufacturing …

This manuscript discusses the role of process systems engineering (PSE) in ensuring quality
manufacturing of Mesenchymal Stem Cells (MSCs) through seeding, cultivation, and …

Clinical trials are research studies performed on people that are aimed at evaluating a
medical, surgical, or behavioural intervention. It is a primary way that researchers find out if a …

The polyester fiber spinning process is extensive, and the involved dynamic models are
complex and difficult to solve analytically. This paper presents the optimal control strategy of …

Chinese hamster ovary (CHO) cells are the workhorse of the multibillion-dollar
biopharmaceuticals industry. They have been extensively harnessed for recombinant …