As an important component of complementary and alternative medicines, traditional
Chinese medicines (TCM) are gaining more and more attentions around the world because …

The natural product berberine (BBR) has become a potential drug in the treatment of
diabetes, hyperlipidemia, and cancer. However, the oral delivery of BBR is challenged by its …

Berberine (BBR) is an isoquinoline plant alkaloid endowed with several pharmacological
activities, including anti-microbial, glucose-and cholesterol-lowering, anti-tumoral and …

The gut microbiota is important in the pathogenesis of energy-metabolism related diseases.
We focused on the interaction between intestinal bacteria and orally administered chemical …

Nitroreductases (NRs) are bacterial enzymes that reduce nitro-containing compounds. We
have previously reported that NR of intestinal bacteria is a key factor promoting berberine …

Herein, we report a Cp* CoIII‐catalyzed C− H activation approach as the key step to create
highly valuable isoquinolones and pyridones as building blocks that can readily be applied …

Objective The objective was to determine the mechanisms of action of berberine (BBR) on
cholesterol homeostasis using in vivo and in vitro models. Methods Male Sprague–Dawley …

Although advances have been made, chemotherapy for chronic, multifactorial diseases such
as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from …

Background Current pain management is limited, in particular, with regard to chronic pain. In
an attempt to discover novel analgesics, we combined the approach developed to …

Background Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood
lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal …