Advances in research on 3C-like protease (3CL pro) inhibitors against SARS-CoV-2 since 2020

R Chen, Y Gao, H Liu, H Li, W Chen, J Ma - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
COVID-19 caused by SARS-CoV-2 in late 2019 is still threatening global human health.
Although some vaccines and drugs are available in the market, controlling the spread of the …

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

J van de Leemput, Z Han - Molecular and cellular biology, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic, responsible for millions of deaths globally. Even with effective vaccines, SARS …

Catalytic dyad residues His41 and Cys145 impact the catalytic activity and overall conformational fold of the main SARS-CoV-2 protease 3-chymotrypsin-like protease

JC Ferreira, S Fadl, AJ Villanueva, WM Rabeh - Frontiers in chemistry, 2021 - frontiersin.org
Coronaviruses are responsible for multiple pandemics and millions of deaths globally,
including the current pandemic of coronavirus disease 2019 (COVID-19). Development of …

[HTML][HTML] Virtual screening and molecular dynamics simulation analysis of Forsythoside A as a plant-derived inhibitor of SARS-CoV-2 3CLpro

S Bibi, MS Khan, SA El-Kafrawy, TA Alandijany… - Saudi Pharmaceutical …, 2022 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a more severe strain of
coronavirus (CoV) that was first emerged in China in 2019. Available antiviral drugs could …

Molecular interactions of tannic acid with proteins associated with SARS-CoV-2 infectivity

M Haddad, R Gaudreault, G Sasseville… - International journal of …, 2022 - mdpi.com
The overall impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on
our society is unprecedented. The identification of small natural ligands that could prevent …

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2

JC Ferreira, S Fadl, WM Rabeh - Journal of Biological Chemistry, 2022 - ASBMB
3C-like protease (3CLpro) processes and liberates functional viral proteins essential for the
maturation and infectivity of severe acute respiratory syndrome coronavirus 2, the virus …

Analyzing 3D structures of the SARS-CoV-2 main protease reveals structural features of ligand binding for COVID-19 drug discovery

L Xu, R Chen, J Liu, TA Patterson, H Hong - Drug Discovery Today, 2023 - Elsevier
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease has an
essential role in viral replication and has become a major target for coronavirus 2019 …

pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity

K Al Adem, JC Ferreira, S Fadl, WM Rabeh - Journal of Biological …, 2023 - ASBMB
3-Chymotrypsin-like protease (3CLpro) is a promising drug target for coronavirus disease
2019 and related coronavirus diseases because of the essential role of this protease in …

Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrate

S Legare, F Heide, BA Bailey-Elkin… - Journal of Biological …, 2022 - ASBMB
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a
global threat to human health has highlighted the need for the development of novel …

A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition

E Heilmann, F Costacurta, S Geley… - Communications …, 2022 - nature.com
Protease inhibitors are among the most powerful antiviral drugs. However, for SARS-CoV-2
only a small number of protease inhibitors have been identified thus far and there is still a …