Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …

A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …

Abstract Dynamic 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)
modifications to DNA regulate gene expression in a cell-type-specific manner and are …

Variable levels of DNA methylation have been reported at tissue-specific differential
methylation regions (DMRs) overlapping enhancers, including super-enhancers (SEs) …

Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian
cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin …

Pluripotent stem cells (PSCs) transition between cell states in vitro, reflecting developmental
changes in the early embryo. PSCs can be stabilized in the naive state by blocking …

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia
(reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The …

α-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several
chromatin-modifying enzymes, including histone demethylases and the Tet family of …

Abstract TAR DNA-binding protein-43 (TDP-43) is known to accumulate in ubiquitinated
inclusions of amyotrophic lateral sclerosis affected motor neurons, resulting in motor neuron …

Germline specification in mammals occurs through an inductive process whereby competent
cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The …