Many proteins contain large structurally disordered regions or are entirely disordered under
physiological conditions. The functions of these intrinsically disordered proteins (IDPs) often …

The hallmark of eukaryotic cells is the nucleus that contains the genome, enclosed by a
physical barrier known as the nuclear envelope (NE). On the one hand, this …

The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper
for the transport between the nucleus and cytosol. The central channel of the NPC is filled …

The transition between the native and amyloid states of proteins can proceed via a
deposition pathway via oligomeric intermediates or via a condensation pathway involving …

Intrinsically disordered proteins (IDPs) are now widely recognized as playing critical roles in
a broad range of cellular functions as well as being implicated in diverse diseases. Their …

Biomolecular polyelectrolyte complexes can be formed between oppositely charged
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …

Highlights•Suboptimal binding motifs lead to frustrated energy landscape.•Non-native,
transient contacts regulate heterogeneity in transition or bound state.•Alternative recognition …

The regulated nucleocytoplasmic exchange of macromolecules is essential for the
eukaryotic cell. However, nuclear transport pathways defined by different nuclear transport …

Nucleoporins (Nups) assemble nuclear pores that form the permeability barrier between
nucleoplasm and cytoplasm. Nucleoporins also localize in cytoplasmic foci proposed to …

Macromolecular cargoes are asymmetrically partitioned in the nucleus or cytoplasm by
nucleocytoplasmic transport (NCT). At the center of this activity lies the nuclear pore complex …