Sex differences in the human brain: a roadmap for more careful analysis and interpretation of a biological reality

AR DeCasien, E Guma, S Liu, A Raznahan - Biology of Sex Differences, 2022 - Springer
The presence, magnitude, and significance of sex differences in the human brain are hotly
debated topics in the scientific community and popular media. This debate is largely fueled …

[HTML][HTML] New insights into the dynamic development of the cerebral cortex in childhood and adolescence: Integrating macro-and microstructural MRI findings

LB Norbom, L Ferschmann, N Parker, I Agartz… - Progress in …, 2021 - Elsevier
Through dynamic transactional processes between genetic and environmental factors,
childhood and adolescence involve reorganization and optimization of the cerebral cortex …

Why and how to account for sex and gender in brain and behavioral research

L Eliot, AK Beery, EG Jacobs, HF LeBlanc… - Journal of …, 2023 - Soc Neuroscience
Long overlooked in neuroscience research, sex and gender are increasingly included as
key variables potentially impacting all levels of neurobehavioral analysis. Still, many …

Greater male than female variability in regional brain structure across the lifespan

LM Wierenga, GE Doucet, D Dima, I Agartz… - Human brain …, 2022 - Wiley Online Library
For many traits, males show greater variability than females, with possible implications for
understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro …

Sex differences in schizophrenia relevant to clinical care

MV Seeman - Expert review of neurotherapeutics, 2021 - Taylor & Francis
Introduction: Most medical diagnoses present somewhat differently in men and women,
more so at specific periods of life. Treatment effects may also differ. This is true for …

X-chromosome influences on neuroanatomical variation in humans

TT Mallard, S Liu, J Seidlitz, Z Ma, D Moraczewski… - Nature …, 2021 - nature.com
The X-chromosome has long been hypothesized to have a disproportionate influence on the
brain based on its enrichment for genes that are expressed in the brain and associated with …

Variability in energy expenditure is much greater in males than females

LG Halsey, V Careau, H Pontzer, PN Ainslie… - Journal of Human …, 2022 - Elsevier
In mammals, trait variation is often reported to be greater among males than females.
However, to date, mainly only morphological traits have been studied. Energy expenditure …

[HTML][HTML] Recommendations for a better understanding of sex and gender in the neuroscience of mental health

LM Wierenga, A Ruigrok, ER Aksnes, C Barth… - … Psychiatry Global Open …, 2024 - Elsevier
There are prominent sex/gender differences in the prevalence, expression, and life span
course of mental health and neurodiverse conditions. However, the underlying sex-and …

The speed of development of adolescent brain age depends on sex and is genetically determined

RM Brouwer, J Schutte, R Janssen… - Cerebral …, 2021 - academic.oup.com
Children and adolescents show high variability in brain development. Brain age—the
estimated biological age of an individual brain—can be used to index developmental stage …

Menstrually-related migraine shapes the structural similarity network integration of brain

X Li, H Hao, Y Li, LWC Au, G Du, X Gao, J Yan… - Cerebral …, 2023 - academic.oup.com
Menstrually-related migraine (MM) is a primary migraine in women of reproductive age. The
underlying neural mechanism of MM was still unclear. In this study, we aimed to reveal the …