Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Host–pathogen interactions provide valuable systems for the study of evolutionary genetics
and natural selection. The sequestration of essential iron has emerged as a crucial innate …

Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

Iron is an essential micronutrient for virtually all eukaryotic organisms and plays a central
role during microbial infections. Invasive fungal diseases are associated with strikingly high …

Invasive fungal infections represent a significant global health problem, and present several
clinical challenges, including limited treatment options, increasing rates of antifungal drug …

Most microorganisms are destroyed by the host tissues through processes that usually
involve phagocytosis and lysosomal disruption. However, some organisms, called …

Iron–sulfur clusters (ISC) are indispensable cofactors for essential enzymes in various
cellular processes. In the model yeast Saccharomyces cerevisiae, the precursor of ISCs is …

Iron acquisition is critical for pathogenic fungi to adapt to and survive within the host
environment. However, to same extent, the fungi must also avoid the detrimental effects …

Iron acquisition is essential for the proliferation of microorganisms, and human pathogens
such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to …

Background The effects of cryptococcemia on patient outcomes in those with or without HIV
remain unclear. Methods One hundred and seventy‐nine cryptococcemia patients were …