If the pace of increase in life expectancy in developed countries over the past two centuries
continues through the 21st century, most babies born since 2000 in France, Germany, Italy …

The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his
article “IL-6: A Cytokine for Gerontologists,” indicated IL-6 as one of the main signaling …

Supercentenarians, people who have reached 110 y of age, are a great model of healthy
aging. Their characteristics of delayed onset of age-related diseases and compression of …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

We analyze the relationship between age of survival, morbidity, and disability among
centenarians (age 100–104 years), semisupercentenarians (age 105–109 years), and …

Late-life loss of independence in daily living is a central concern for the aging individual and
for society. The implications of increased survival to advanced age may be different at the …

Exceptional longevity represents an extreme phenotype. Current centenarians are survivors
of a cohort who display delayed onset of age-related diseases and/or resistance to …

Human longevity may be found in single individuals as well as in the population as a whole
(“population longevity”). Longevity Blue Zones (LBZs), which are areas with an unusually …

Background Centenarians and supercentenarians with exceptional longevity are excellent
models for research towards improvements of healthy life expectancy. Extensive research …

Background The strong familiality of living to extreme ages suggests that human longevity is
genetically regulated. The majority of genes found thus far to be associated with longevity …