Mammalian orthoreovirus (reovirus) is under development as a cancer virotherapy. Clinical
trials demonstrate that reovirus-based therapies are safe and tolerated in patients with a …

Reovirus, a double-stranded ribonucleic acid virus and benign human pathogen,
preferentially infects and kills cancer cells in its unmodified form, and is one of the leading …

Oxidative stress (OS)-induced senescence of the amniochorion has been associated with
parturition at term. We investigated whether telomere fragments shed into the amniotic fluid …

Background/Aims: Colorectal cancer (CRC) is one of the leading causes of cancer-related
death worldwide. Levistolide A (LA), a natural compound isolated from the traditional …

The last few years have seen an increased interest in immunotherapy in the treatment of
malignant disease. In particular, there has been significant enthusiasm for oncolytic …

Premature proliferative arrest in benign or early-stage tumors induced by oncoproteins,
chromosomal instability, or DNA damage is associated with p53/p21 activation, culminating …

Pelareorep (REOLYSIN®) is an investigational new drug, a proprietary formulation
consisting of a live, replication-competent, naturally occurring Reovirus Type 3 Dearing …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumor types
worldwide. BET inhibitors display anti-tumor activity in pancreatic cancer, however the cells …

The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host
relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of …

Breast cancer is the second leading cause of cancer-related deaths in women in the United
States. The triple-negative breast cancer (TNBC) subtype associates with higher rates of …