Biological heterogeneity in diffuse large B cell lymphoma (DLBCL) is partly driven by cell-of-
origin subtypes and associated genomic lesions, but also by diverse cell types and cell …

Immuno-oncology has traditionally focused on the cellular arm of the adaptive immune
response, while attributing tumor-promoting activity to humoral responses in tumor-bearing …

Most B cell lymphomas arise from the oncogenic transformation of B cells that have
undergone the germinal center (GC) reaction of the T cell-dependent immune response …

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell
lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of …

Multicellular life requires altruistic cooperation between cells. The adaptive immune system
is a notable exception, wherein germinal center B cells compete vigorously for limiting …

Vitreoretinal lymphoma (VRL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL)
considered a variant of primary central nervous system lymphoma (PCNSL). The diagnosis …

Diffuse large B-cell lymphoma (DLBCL) with aberrant coexpression of CD10+ BCL6+
MUM1+ (DLBCL-AE), classified as germinal center B cell (GCB) type by the Hans algorithm …

Unique molecular vulnerabilities have been identified in the aggressive MCD/C5 genetic
subclass of diffuse large B-cell lymphoma (DLBCL). However, the premalignant cell-of-origin …

Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma curable even in
advanced stages. DLBCL involving the central nervous system (CNS) is more difficult to cure …

Large B-cell lymphoma of immune-privileged sites (LBCL-IP) arise in immune sanctuaries
including the testis and central nervous system (CNS). After initially reaching complete …