The type I interferon pathway has been implicated in the pathogenesis of a number of
rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis …

Introduction Rheumatoid arthritis (RA) is a chronic systemic disease characterized by
articular involvement and extra-articular manifestations. The incidence and prevalence of …

Our understanding of the genetic basis of systemic lupus erythematosus has progressed
rapidly in recent years. While many genetic polymorphisms have been associated with …

The association between smoke habit and autoimmunity has been hypothesized a long time
ago. Smoke has been found to play a pathogenic role in certain autoimmune disease as it …

OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple
autoantibodies and from multiple autoantibodies to type 1 diabetes in young children …

Systemic lupus erythematosus (SLE; OMIM 152700) is a highly heterogeneous disorder,
characterized by differences in autoantibody profile, serum cytokines, and a multi-system …

T lymphocytes play a central role in regulation of the immune system. Both effector and
regulatory T cells work in equilibrium to provide optimal immune response against foreign …

The aim of this work was to identify common HLA Class II alleles contributing to primary
Sjögren's syndrome (pSS) susceptibility worldwide and to analyze their biological …

Endocannabinoids are key bioactive components of the endocannabinoid system, and the
profound influence of endocannabinoids on the modulation of the immune system is being …

Host genetic factors play a major role in determining differential susceptibility to major
infectious diseases of humans, such as malaria, HIV/AIDS, tuberculosis, and invasive …