Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …

Following synthesis, tRNAs are peppered by numerous chemical modifications which may
differentially affect a tRNA's structure and function. Although modifications affecting the …

RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

The strategies organisms use to decode synonymous codons in cytosolic protein synthesis
are not uniform. The complete isoacceptor tRNA repertoire and the type of modified …

This volume is a timely and comprehensive description of the many facets of DNA and RNA
modification-editing processes and to some extent repair mechanisms. Each chapter offers …

Two previously undetected domains were identified in a variety of RNA-binding proteins,
particularly RNA-modifying enzymes, using methods for sequence profile analysis. A small …

The discovery of∼ 20-kb gene clusters containing a family of paralogs of tRNA guanosine
transglycosylase genes, called tgtA5, alongside 7-cyano-7-deazaguanine (preQ0) synthesis …

Transfer RNA (tRNA) canonically has the clover-leaf secondary structure with the acceptor,
D, anticodon, and T arms, which are folded into the L-shaped tertiary structure. To …

Queuosine (Q) is a hypermodified 7-deazaguanosine nucleoside located in the anticodon
wobble position of four amino acid-specific tRNAs. In bacteria, Q is produced de novo from …

Chemically altered nucleosides derived from canonical ribo-or deoxyribonucleoside-
derivatives of adenosine, cytosine, guanosine, and uridine or thymidine are found in all …