Methylglyoxal (MG) is a highly reactive α-ketoaldehyde formed endogenously as a
byproduct of the glycolytic pathway. To remove MG, various detoxification systems work …

Current pharmacotherapies for depression exhibit slow onset, side effects and limited
efficacy. Therefore, identification of novel fast-onset antidepressants is desirable. GLO1 is a …

Abstract Glyoxalase 1 (Glo1) is the first enzyme involved in glutathione-dependent
detoxification of methylglyoxal, eventually generating d-lactate by the second enzyme …

We previously identified a 210 kb region on chromosome 11 (50.37-50.58 Mb, mm10)
containing two protein-coding genes (Hnrnph1, Rufy1) that was necessary for reduced …

Previous studies showed that the glyoxalase 1 (Glo1) gene modulates anxiety-like behavior,
seizure susceptibility, depression-like behavior, and alcohol drinking in the drinking-in-the …

Background Glyoxalase 1 (GLO 1) is an enzyme that metabolizes methylglyoxal (MG), which
is a competitive partial agonist at GABAA receptors. Inhibition of GLO 1 increases …

Autism spectrum disorder (ASD) is a severe neurological and developmental disorder that
impairs a person's ability to socialize and communicate and affects behavior. The number of …

An increase in opioid-overdose deaths was evident before the COVID-19 pandemic, and
has escalated since its onset. Fentanyl, a highly potent synthetic opioid, is the primary driver …

Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute
ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but …

Recent research shows that more women are partaking in heavy drinking, binge drinking,
and risky drinking behaviors compared to previous years. These behaviors are key …