The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …

Background The complement cascade not only provides protection from infection but can
also mediate destructive inflammation. Complement is also involved in elimination of …

The immune system has evolved to protect the host from a universe of pathogenic microbes
that are themselves constantly evolving. The immune system also helps the host eliminate …

The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

Neutrophil extracellular traps (NETs) facilitate the extracellular killing of pathogens.
However, in recent years, excessive NET formation has been implicated in several …

The complement activation product C3a is often described as a proinflammatory mediator,
alongside its downstream cousin, C5a. However, emerging studies show that C3a has …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …