Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

The prevalence of malignant hypertension has clearly fallen with the advent of anti-
hypertensive medication but has remained stable over the past 30–40 years in spite of …

688 Hypertension October 2017 clinical patterns of HIRD susceptibility schematically
illustrated in Figure 1 with respect to the BP threshold for HIRD and the slopes of the …

Acute kidney injury (AKI) is a major complication in hospitalized patients and is associated
with elevated mortality rates. Numerous recent studies indicate that AKI also significantly …

Malignant hypertension (MHT) still remains a severe condition that requires early
recognition and treatment. Over the years, the prevention and treatment of MHT have …

Background: The present study in Sprague-Dawley rats determined the effects of a rapid rise
of renal perfusion pressure (RPP) upon the activation of mTOR (mechanistic target of …

The relative contribution of self-perpetuating versus hemodynamic-induced fibrosis to the
progression of chronic kidney disease (CKD) after acute kidney injury (AKI) is unclear. In the …

ANG II is thought to increase the susceptibility to hypertension-induced renal disease (HIRD)
via blood pressure (BP)-dependent and BP-independent pathways; however, the …

The pathogenic links between elevated blood pressure and chronic kidney disease remain
obscure. This article examines progress in population genetics and in animal models of …

Background Renal autoregulation maintains stable renal function despite BP fluctuations
and protects glomerular capillaries from hypertensive injury. However, real-time dynamics of …