Many bacteria, both environmental and pathogenic, exhibit the property of autoaggregation.
In autoaggregation (sometimes also called autoagglutination or flocculation), bacteria of the …

Carbohydrates have long been known to mediate intracellular interactions, whether within
one organism or between different organisms. Sialic acids (Sias) are carbohydrates that …

Autotransporters are the core component of a molecular nano-machine that delivers cargo
proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion …

With the immense progress in drug delivery systems (DDS) and the rise of nanotechnology,
challenges such as target specificity remain. The vesicle-vector system (VVS) is a delivery …

Escherichia coli is primarily known as a commensal colonising the gastrointestinal tract of
infants very early in life but some strains being responsible for diarrhoea, which can be …

Gram-negative bacteria harness multiple protein secretion systems and secrete a large
proportion of the proteome. Proteins can be exported to periplasmic space, integrated into …

The formation of aggregates and biofilms enhances bacterial colonisation and infection
progression by affording protection from antibiotics and host immune factors. Despite these …

Shigella flexneri is an intracellular bacterial pathogen that invades epithelial cells in the
colonic mucosa, leading to bloody diarrhea. A previous study showed that S. flexneri forms …

Biosafety of engineered bacteria as living therapeutics requires a tight regulation to control
the specific delivery of protein effectors, maintaining minimum leakiness in the uninduced …

Autotransporters are the largest family of outer membrane and secreted proteins in Gram-
negative bacteria. Most autotransporters are localised to the bacterial surface where they …