Breakthrough methods in machine learning (ML), protein structure prediction, and novel
ultrafast structural aligners are revolutionizing structural biology. Obtaining accurate models …

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB),
funded by the United States National Science Foundation, National Institutes of Health, and …

The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …

Depression is a common mental illness, which is related to monoamine neurotransmitters
and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems …

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine
receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators …

Nicotinic acetylcholine receptors (nAChRs) present as many different subtypes in the
nervous and immune systems, muscles and on the cells of other organs. In the immune …

Nicotinic acetylcholine receptors (nAChRs) comprise a family of pentameric ligand-gated ion
channels widely distributed in the central and peripheric nervous system and in non …

The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …

Order and disorder govern protein functions, but there is a great diversity in disorder, from
regions that are—and stay—fully disordered to conditional order. This diversity is still difficult …

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of pentameric, ligand-
gated ion channels that are located on the surface of neurons and non-neuronal cells and …