The impact of tRNA modifications on translation in cancer: identifying novel therapeutic avenues
AM Añazco-Guenkova, B Miguel-López… - NAR …, 2024 - academic.oup.com
Recent advancements have illuminated the critical role of RNA modifications in post-
transcriptional regulation, shaping the landscape of gene expression. This review explores …
transcriptional regulation, shaping the landscape of gene expression. This review explores …
Schizosaccharomyces pombe pus1 mutants are temperature sensitive due to decay of tRNAIle (UAU) by the 5'-3'exonuclease Dhp1, primarily targeting the unspliced …
F Stegemann, E Marcus, S Neupert, S Ostrowski… - RNA, 2025 - rnajournal.cshlp.org
The pseudouridylase Pus1 catalyzes pseudouridine (Ψ) formation at multiple uridine
residues in tRNAs, and in some snRNAs and mRNAs. Although Pus1 is highly conserved …
residues in tRNAs, and in some snRNAs and mRNAs. Although Pus1 is highly conserved …
The conserved wobble uridine tRNA thiolase Ctu1 is required for angiogenesis and embryonic development
Y Yu, C Wang, Y Wang, H Shi, H Hu, Y Du, Z Zhou - PloS one, 2024 - journals.plos.org
Cytosolic thiouridylase is a conserved cytoplasmic tRNA thiolase composed of two different
subunits, CTU1 and CTU2. CTU2 serves as a scaffold protein, while CTU1 catalyzes the 2 …
subunits, CTU1 and CTU2. CTU2 serves as a scaffold protein, while CTU1 catalyzes the 2 …
[HTML][HTML] Transfer RNA acetylation regulates in vivo mammalian stress signaling
Transfer RNA (tRNA) modifications are crucial for protein synthesis, but their position-
specific physiological roles remain poorly understood. Here we investigate the impact of N4 …
specific physiological roles remain poorly understood. Here we investigate the impact of N4 …
Essentiality and dynamic expression of the human tRNA pool during viral infection
N Aharon-Hefetz, M Schwartz, O Dahan… - bioRxiv, 2024 - biorxiv.org
Human viruses depend on the translation resources of the host cell. A significant translation
resource is the tRNA pool of the cell, as human viruses do not encode tRNA genes. Through …
resource is the tRNA pool of the cell, as human viruses do not encode tRNA genes. Through …
Synergistic effects of tRNA modification defects in Escherichia coli K12
JM Bacusmo, J Babor, J Hu, B Cao, S Kellner… - bioRxiv, 2024 - biorxiv.org
Abstract tRNAs are the central adaptor molecule in translation and require a wide variety of
post-transcriptional modifications to fulfill their functions. The model gram-negative …
post-transcriptional modifications to fulfill their functions. The model gram-negative …