While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

It is well established that the immune system can identify and destroy neoplastic transformed
cells in a process known as immunosurveillance. Most studies have focused on the classical …

Coreceptor CD4 and CD8αβ double-negative (DN) TCRαβ+ intraepithelial T cells, although
numerous, have been greatly overlooked and their contribution to the immune response is …

Uncontrolled BK polyomavirus (BKPyV) replication in kidney transplant recipients (KTRs)
causes polyomavirus-associated nephropathy and allograft loss. Reducing …

We show that Leishmania donovani–infected macrophages (MΦs) are capable of
stimulating MHC class II (MHC-II)–restricted T cells at 6 h of infection. At 48 h, infected MΦs …

Autologous blood transfusion is an important blood protection measure. Red blood cells
have a certain degree of immunogenicity and their surface membrane proteins CD28 and …

Unlike the polymorphic MHC class Ia molecules, MHC class Ib molecules are oligomorphic
or nonpolymorphic. We recently discovered a protective CD8 T cell response to mouse …

CD8+ T lymphocytes are the major immunocytes responsible for host defense against viral
infection. The ligand for a CD8+ T cell receptor consists of a short peptide derived from a …

The murine major histocompatibility complex (MHC) class Ib region encodes more than 20
proteins with diverse biological functions, and many have not been characterized. Evidence …

Abstract Major Histocompatibility Complex (MHC) class I molecules present intracellular
peptides to CD8 T cells to mediate pathogen surveillance. In contrast to the highly …