The procurement and management of nutrients and ability to fight infections are fundamental
requirements for survival. These defense responses are bioenergetically costly, requiring …

Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past,
elesclomol was recognized as an inducer of oxidative stress, but now it has also been found …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia
(CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The …

Involvement of TIGIT in Natural Killer Cell Exhaustion and I... : Hepatology Involvement of
TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Aberrant RNA modifications lead to dysregulated gene expression and cancer progression.
Ribosomal RNA (rRNA) accounts for more than 80% of a cell's total RNA, but the functions …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults, is
a clinically and genetically heterogeneous disease that is further classified into …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …