Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

Abstract The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway plays an essential
role in glucose metabolism, promoting glycolysis and resisting gluconeogenesis. PI3K/AKT …

Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation
and oncogenesis. LMP1's transforming activity depends on its C-terminal activation region 2 …

Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. This severe stress is …

The tumor necrosis factor receptor (TNFR)-associated factor (TRAF) family of molecules are
intracellular signaling adaptors and control diverse signaling pathways mediated not only by …

Posttranslational modification of proteins via ubiquitination determines their activation,
translocation, dysregulation, or degradation. This process targets a large number of cellular …

Autophagy, a conserved cellular degradative process, plays a crucial role in innate immunity
during viral infections. Nervous necrosis virus (NNV), a leading cause of fish diseases with …

The process of ubiquitination regulates the degradation, transport, interaction, and
stabilization of substrate proteins, and is crucial for cell signal transduction and function. TNF …

Tumor necrosis factor receptor-associated factors (TRAFs) have been studied in a few
mollusks and participate in various biological processes, like apoptosis, immune response …

Tumor necrosis factor receptor-associated factor 3 (TRAF3) is one of the intracellular
adaptor proteins for the innate immune response, which is involved in signaling regulation in …