The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
Antitumor activity of rutaecarpine in human colorectal cancer cells by suppression of wnt/β-catenin signaling
Alkaloids derived from natural products have been traditionally used to treat various
diseases, including cancers. Rutaecarpine (1), a β-carboline-type alkaloid obtained from …
diseases, including cancers. Rutaecarpine (1), a β-carboline-type alkaloid obtained from …
Antitumor activity of pulvomycin via targeting activated-STAT3 signaling in docetaxel-resistant triple-negative breast cancer cells
Although docetaxel-based regimens are common and effective for early-stage triple-
negative breast cancer (TNBC) treatment, acquired drug resistance frequently occurs …
negative breast cancer (TNBC) treatment, acquired drug resistance frequently occurs …
Role of histone demethylases and histone methyltransferases in triple-negative breast cancer: Epigenetic mnemonics
Triple-negative breast cancer (TNBC) is a particularly lethal subtype of breast cancer owing
to its heterogeneity, high drug resistance, poor prognosis and lack of therapeutic targets …
to its heterogeneity, high drug resistance, poor prognosis and lack of therapeutic targets …
A novel small molecule STAT3 inhibitor SLSI-1216 suppresses proliferation and tumor growth of triple-negative breast cancer cells through apoptotic induction
SK Park, WS Byun, S Lee, YT Han, YS Jeong… - Biochemical …, 2020 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer,
characterized by the lack of expression of estrogen receptor, progesterone receptor, and …
characterized by the lack of expression of estrogen receptor, progesterone receptor, and …
Antitumor activity of asperphenin B by induction of apoptosis and regulation of glyceraldehyde-3-phosphate dehydrogenase in human colorectal cancer cells
Colorectal cancer (CRC) is a common and intractable malignancy with a high mortality risk.
Conventional chemotherapeutics are effective for patients with early stage CRC, but the …
Conventional chemotherapeutics are effective for patients with early stage CRC, but the …
Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity
Disruptor of telomeric silencing-1 like (DOT1L) is a histone H3 methyltransferase which
specifically catalyzes the methylation of histone H3 lysine-79 residue. Recent findings …
specifically catalyzes the methylation of histone H3 lysine-79 residue. Recent findings …
[HTML][HTML] DOT1L promotes expression of CD44 through the Wnt/β-catenin signaling pathway in early gastric carcinoma
P Li, Z Zhang, P Sun - Journal of Cancer, 2024 - ncbi.nlm.nih.gov
To assess telomere silencing 1-like (DOTIL) gene expression within gastric cancer (GC)
tissues as well as its function of promoting cancer stem cell (CSC)-mediated epithelial …
tissues as well as its function of promoting cancer stem cell (CSC)-mediated epithelial …
Repurposing Drugs as Novel Triple-negative Breast Cancer Therapeutics
Background: Triple-Negative Breast Cancer (TNBC) is the most aggressive form of Breast
Cancer (BC), with high rates of metastasis and recurrence and limited treatment options …
Cancer (BC), with high rates of metastasis and recurrence and limited treatment options …
Inhibition of DOT1L by Half-Selenopsammaplin A Analogs Suppresses Tumor Growth and EMT-Mediated Metastasis in Triple-Negative Breast Cancer
WS Byun, GH Lee, H Park, SK Lee - Pharmaceuticals, 2020 - mdpi.com
Due to a lack of hormone receptors, current treatment strategies for triple-negative breast
cancer (TNBC) are limited with frequent disease recurrence and metastasis. Recent findings …
cancer (TNBC) are limited with frequent disease recurrence and metastasis. Recent findings …