Three inhibitors of CDK4/6 kinases were recently FDA approved for use in combination with
endocrine therapy, and they significantly increase the progression-free survival of patients …

Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …

Cyclin-dependent kinase 6 (CDK6) is an important regulator of the cell cycle. Together with
CDK4, it phosphorylates and inactivates retinoblastoma (Rb) protein. In tumour cells, CDK6 …

This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

The sustained cell proliferation resulting from dysregulation of the cell cycle and activation of
cyclin-dependent kinases (CDKs) is a hallmark of cancer. The inhibition of CDKs is a highly …

Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …

Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

Pleiotropic intervention has prominent advantages for complex pathomechanisms, such as
Alzheimer's disease (AD). In this study, a series of novel 3-(4-pyridyl)-5-(4-sulfamido-phenyl) …

The discovery of cyclin-dependent kinases (CDK) and their mechanism in regulating the cell
cycle process was considered a game-changer in cancer therapy. Cell cycle arrest and …

Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell.
Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase …