DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2
(CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase …

Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of
almost half human population. It has evolved to escape immune surveillance, establishes …

Cell cycle checkpoints were initially presumed to function as a regulator of cell cycle
machinery in response to different genotoxic stresses, and later found to play an important …

ABSTRACT Introduction: Ataxia-telangiectasia (AT) a multisystem disorder primarily
characterized by cerebellar degeneration, telangiectasia, immunodeficiency, cancer …

Abstract Introduction Ataxia–Telangiectasia (AT) syndrome is an autosomal recessive
neurodegenerative disorder characterized by cerebellar ataxia, oculocutaneous …

Ionizing radiation may be of both artificial and natural origin and causes cellular damage in
living organisms. Radioactive isotopes have been used significantly in cancer therapy for …

Abstract Hypermethylated-in-Cancer 1 (Hic1) is a tumor suppressor gene frequently
inactivated by epigenetic silencing and loss-of-heterozygosity in a broad range of cancers …

DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …

Accumulating evidence suggests that dormant DNA replication origins play an important role
in the recovery of stalled forks. However, their functional interactions with other fork recovery …