The role of microglia in diabetic retinopathy: inflammation, microvasculature defects and neurodegeneration

C Altmann, MHH Schmidt - International journal of molecular sciences, 2018 - mdpi.com
Diabetic retinopathy is a common complication of diabetes mellitus, which appears in one
third of all diabetic patients and is a prominent cause of vision loss. First discovered as a …

Lipid metabolism dysregulation in diabetic retinopathy

JV Busik - Journal of lipid research, 2021 - ASBMB
Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

Multiplatform metabolomics reveals novel serum metabolite biomarkers in diabetic retinopathy subjects

Q Xuan, Y Ouyang, Y Wang, L Wu, H Li… - Advanced …, 2020 - Wiley Online Library
Diabetic retinopathy (DR) is the main cause of vision loss or blindness in working age adults
worldwide. The lack of effective diagnostic biomarkers for DR leads to unsatisfactory curative …

Role of ceramides in the pathogenesis of diabetes mellitus and its complications

N Mandal, R Grambergs, K Mondal, SK Basu… - Journal of Diabetes and …, 2021 - Elsevier
Diabetes mellitus (DM) is a systemic metabolic disease that affects 463 million adults
worldwide and is a leading cause of cardiovascular disease, blindness, nephropathy …

[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

Advances in bone marrow stem cell therapy for retinal dysfunction

SS Park, E Moisseiev, G Bauer, JD Anderson… - Progress in retinal and …, 2017 - Elsevier
The most common cause of untreatable vision loss is dysfunction of the retina. Conditions,
such as age-related macular degeneration, diabetic retinopathy and glaucoma remain …

[HTML][HTML] The role of dyslipidemia in diabetic retinopathy

SS Hammer, JV Busik - Vision research, 2017 - Elsevier
Diabetic retinopathy (DR) affects over 93 million people worldwide and is the number one
cause of blindness among working age adults. These indicators coupled with the projected …

Concise review: perspectives and clinical implications of bone marrow and circulating stem cell defects in diabetes

GP Fadini, S Ciciliot, M Albiero - Stem Cells, 2017 - academic.oup.com
Diabetes mellitus is a complex systemic disease characterized by severe morbidity and
excess mortality. The burden of its multiorgan complications relies on an imbalance between …

Common mechanisms underlying diabetic vascular complications: focus on the interaction of metabolic disorders, immuno-inflammation, and endothelial dysfunction

C Xue, K Chen, Z Gao, T Bao, LS Dong, L Zhao… - Cell Communication and …, 2023 - Springer
Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …

Perilipin 2–positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARγ-dependent vasodegeneration

G Blot, R Karadayi, L Przegralek… - The Journal of …, 2023 - Am Soc Clin Investig
Type 2 diabetes mellitus (T2DM), characterized by hyperglycemia and dyslipidemia, leads to
nonproliferative diabetic retinopathy (NPDR). NPDR is associated with blood-retina barrier …